“Epigenetics and DNA Damage” edited by Miriam Galvonas Jasiulionis is an authoritative volume in the 「Translational Epigenetics」 series that delves into the molecular crosstalk between chromatin regulation and DNA repair processes 🧬✨. Comprising 15 chapters, this work systematically reviews how DNA methylation, histone modifications, non-coding RNAs, and chromatin remodelers influence the detection and resolution of DNA lesions, and vice versa, highlighting implications for metabolism, aging, stem-cell biology, immune function, and cancer therapies 🔬🔄📚. Written by leading experts, it equips graduate students and researchers with both the conceptual framework and practical protocols needed to explore novel epigenetic interventions in disease contexts 🤓💡.
「Editor:」 Miriam Galvonas Jasiulionis, Professor, Dept. of Pharmacology, Universidade Federal de São Paulo, Brazil
「Format:」 336 pages; Paperback (ISBN 978-0-323-91081-1) and eBook (ISBN 978-0-323-91082-8)
「Publisher:」 Academic Press / Elsevier; list price $175.00
“This volume offers a thorough foundation in epigenetics and DNA damage research, with contributions from international experts and protocols for DNA damage and epigenetic alteration analyses”.
Why This Book?
「Complex Interplay:」 While the roles of epigenetic marks and DNA repair individually are well studied, their dynamic interdependence remains poorly characterized. This book bridges that gap by examining spatial–temporal coordination between chromatin state and DNA-damage response 🔄🕰️.
「Translational Focus:」 Beyond basic science, authors discuss how mechanistic insights can inform novel diagnostics and therapies, such as combining DNA-damaging agents with epigenetic modulators in cancer treatment 🎯💊.
Key Themes and Chapters
1. DNA Methylation and Damage
Explores how base modifications affect lesion susceptibility and repair factor recruitment, and conversely how repair events reshape methylation landscapes 🔍🧩.
2. Histone Modifications in Repair
Details roles of histone acetylation, methylation, ubiquitylation, and phosphorylation in double-strand break repair and nucleotide excision repair pathways 🎨🔧.
3. Histone Variants and Chromatin Remodeling
Examines incorporation of H2A.X, macroH2A, and other variants at damage sites, and ATP-dependent remodelers that mobilize nucleosomes to facilitate access 🚧🔄.
4. Non-coding RNAs (miRNAs, lncRNAs)
Surveys how small and long non-coding RNAs fine-tune damage signaling, repair complex stability, and chromatin architecture at lesion sites 🧵🎗️.
5. Metabolism, Aging, and Cellular Differentiation
Links metabolic state and sirtuin-mediated histone deacetylation to genome stability during aging, and discusses epigenetic drives of lineage commitment under genotoxic stress 🍃⏳.
6. Immune Function and Stem Cell Biology
Investigates how DNA damage in hematopoietic stem cells affects epigenomic fidelity, with implications for immunosenescence and leukemogenesis 🧫🧬.
7. Cancer: From Mechanism to Therapy
Covers radiotherapy-induced DNA lesions, chemotherapeutic damage, and adjunctive use of DNA methyltransferase or histone deacetylase inhibitors to tip the balance against tumor survival 🎗️⚔️.
Translational Applications and Protocols
「Epigenetic Therapies:」 Strategies combining DNA-damaging modalities with epigenetic drugs for synergistic cancer killing, including timing and dosage considerations 🔬💥.
「Analytical Methods:」 Step-by-step guidance for detecting DNA breaks (e.g., comet assay, γ-H2AX foci) alongside genome-wide methylation and chromatin‐accessibility assays 🧪📝.
Context within the Series
As the 33rd volume of Translational Epigenetics—now a 49-entry series—this book continues the mission of marrying fundamental epigenetic insights to real-world biomedical challenges, alongside titles on aging, cancer prevention, stress epigenetics, and more 🌐📚.
About the Editor
「Dr. Miriam Galvonas Jasiulionis」 leads the Laboratory of Ontogeny and Epigenetics at Universidade Federal de São Paulo. Her research on stress-induced epigenetic shifts in melanocyte transformation has appeared in Clinical Epigenetics, Molecular Oncology, and Frontiers in Immunology, underscoring her expertise in melanoma biology and epigenetic therapeutics 🏅🔬.
How to Use This Book
「For Students:」 Read foundational chapters on DNA methylation and histone biology to build conceptual clarity before tackling advanced translational applications.
「For Researchers:」 Apply the provided protocols directly in your lab; adapt therapeutic strategy chapters to design combinatorial drug trials.
「For Educators:」 Assign relevant sections for graduate seminars on chromatin dynamics, DNA repair, and cancer epigenetics 🎓📖.
Conclusion
“Epigenetics and DNA Damage” stands out as a meticulously curated resource that unites mechanistic depth with practical application. Whether your aim is to decipher the epigenomic aftermath of genotoxic stress or to pioneer epigenetic-based therapies, this volume will guide and inspire your next discoveries 💡🔍.
Dive deeper into this comprehensive volume to elevate your understanding of how our genome’s packaging informs, and is informed by, the ever-present challenge of DNA damage!
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